European Pain School®

at the University of Siena

European Pain School®

at the University of Siena

EPS 2023 • Neuro-immune Interactions in Nociception, Pain and Itch

Siena, Italy • 10-17 June 2023

Neuro-immune Interactions in Nociception, Pain and Itch

Siena, Italy • 10-17 June 2023


Ln Faculty Lectures (L1-L18)
Sn Scholars’ Oral Presentations (S1-S39)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W10)

  • 10 June
  • 11 June
  • 12 June
  • 13 June
  • 14 June
  • 15 June
  • 16 June
  • 17 June
  • Saturday, 10 June

    11:00-17:00 Arrival of Scholars and Faculty at the Certosa di Pontignano
    Assignment to rooms in the hotel wing of the Certosa. All food during the week will be provided by the restaurant of the Certosa (breakfast, lunch and dinner).
    15:00-16:30 Guided Certosa tour by G. Carli
    17:15-17:30 Welcome and Opening Ceremony
    17:45-18:45 L1 Pain control by immunotherapies and regenerative medicine
    Ru-Rong Ji (Durham, NC, USA)
    20:00 Dinner


  • Sunday, 11 June

    9:00-10:00 L2 From Genes to analgesic drugs - how mouse and human genetics are contributing to pain therapies
    John N. Wood (London, United Kingdom)
    10:00-10:15 S1 CCL2-induced desensitization of μ-opioid receptors in the spinal cord dorsal horn is reduced by endogenous TRPV1 agonist N-oleoyldopamine
    Mario Heles (Prague, Czech Republic)
    10:15-10:30 S2 Characterization of trigeminal sensory neurons innervating the temporomandibular joint
    Jessie Alfaro (San Antonio, TX, USA)
    11:00-11:15 S3 Characterization of the anti-nociceptive effect of baricitinib in the collagen antibody induced arthritis mouse model
    Nils Simon (Stockholm, Sweden)
    10:45-11:15 Coffee break
    11:15-11:30 S4 Stress exposure promotes long-term widespread hypersensitivity in a mouse model of joint pain
    Roxana Florea (London, United Kingdom)
    11:30-11:45 S5 Pro-inflammatory macrophages communicate with dorsal root ganglia neurons through miR-155 enriched extracellular vesicles
    Francesca Picco (London, United Kingdom)
    11:45-12:45 L3 Neuroimmune interaction in arthritis pain
    Marzia Malcangio (London, United Kingdom)
    12:45-15:00 Lunch break
    15:00-16:00 L4 Pain control by specialized pro-resolving mediators via neuro, immune, and glial modulation
    Ru-Rong Ji (Durham, NC, USA)
    16:00-16:15 S6 Dorsal root ganglia exosomes: focus on biological function and sensory neuron-glia crosstalk
    Vincenzo Prato (Leeds, United Kingdom)
    16:15-16:30 S7 Contribution of immune cells to oxaliplatin-induced cold allodynia in mice
    Nicole Richter (Erlangen,Germany)
    16:30-16:45 S8 Citral-induced scratching behavior and antinociception
    Sacha Aubrey Alves Rodrigues Santos (Fortaleza, Brazil)
    16:45-17:15 Coffee break
    17:15-17:30 S9 Preliminary results from an open trial using transcranial direct current stimulation (tDCS) to treat chronic pain and comorbid psychiatric disorders in veterans using brain-derived neurotrophic factor (BDNF) as a marker of treatment response
    Natalie Hellman (Atlanta, GA, USA)
    17:30-17:45 S10 Local field potential change during euthanasia
    Julieta Trejo (Arlington, TX, USA)
    17:45-18:45 L5 Ethics in pain: treatment of babies in pain
    Carlo V. Bellieni (Siena, Italy)
    20:00-21:30 Dinner
    21:30 W1 Debate teams


  • Monday, 12 June

    9:00-10:00 L6 Interactions of chronic pain, stress, anxiety and depression: their role in central sensitization (human and animal data)
    Zsuzsanna Helyes (Pécs, Hungary)
    10:00-10:15 S11 Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain
    Sara Caxaria (London, United Kingdom)
    10:15-10:30 S12 Psilocybin: the future of chronic pain treatment?
    Tate Askey (Reading, United Kingdom)
    10:30-10:45 S13 Sigma-1 receptor inhibition reduces mechanical allodynia and modulate neuroinflammation in a model of chronic neuropathic pain
    Simona Denaro (Catania, Italy)
    10:45-11:15 Coffee break
    11:15-11:30 S14 Role of central and peripheral TREK1 channels in nociception, itch and cognitive function
    Romane Boyer (Clermont-Ferrand, France)
    11:30-11:45 S15 TIMP-1 as an effector of inflammatory pain via regulation of immune cell-derived molecules in the dorsal root ganglia
    Rena Stair (Kansas City, KS, USA)
    11:45-12:45 L7 Quantitative Sensory Testing (QST): from small fibers to central pain processing
    Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel)
    12:45-15:00 Lunch break
    15:00-16:30 W2 Pain Labs
    Thermode stimulation, QST
    Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel)
    Neurogenic inflammation, local anesthesia, primary hyperalgesia, QST
    Peter Reeh (Erlangen, Germany)
    16:00-16:15 S16 Certainty in sensations as a modulator of the effects of top-down mechanisms on pain perception
    Mariana Agostinho (Lisbon, Portugal)
    16:45-17:15 Coffee break
    17:15-17:30 S17 Gq-mediated inhibition of TRPM8 by the prostacyclin receptor
    Teodora Stratulat (Bucharest, Romania)
    17:30-17:45 S18 Role of the RANK-RANKL-OPG axis in modulating inflammatory responses in astrocytes
    Sofia Passaponti (Siena, Italy)
    17:45-18:45 L8 Regulation of anti-viral immune responses by primary sensory neurons
    Sophie Ugolini (Marseille, France)
    20:00-21:30 Dinner
    21:30 W3 QST experience


  • Tuesday, 13 June

    9:00-10:00 L9 Neural control of inflammation: the inflammatory reflex
    Davide Martelli (Bologna, Italy)
    10:00-10:30 W4 Duetto Do sensory neurons suppress or activate innate immunity?
    Sophie Ugolini (Marseille, France) and Ru-Rong Ji (Durham, NC, USA)
    10:30-10:45 S19 Sex-related nociceptive pain behavioral differences due to adolescent stress can predispose low back pain in adulthood in rats
    Deepika Singhal (Heidelberg, Germany)
    10:45-11:15 Coffee break
    11:15-11:30 S20 Alterations of peripheral blood mononuclear cell (PBMC) transcriptomics and plasma metabolite composition in mice exposed to chronic restraint stress
    Ágnes Király (Pécs, Hungary)
    11:30-11:45 S21 The antimalarial artemisinin is an agonist of the transient receptor potential ankyrin type 1 receptor-channel expressed in dorsal root and nodose ganglia neurons
    George Oprita (Bucharest, Romania)
    11:45-12:45 L10 Development of a novel multi-target analgesic candidate: from discovery to phase I clinical trials (an example for successful cooperation between academic research and industry)
    Zsuzsanna Helyes (Pécs, Hungary)
    12:45-15:00 Lunch break
    15:00-16:00 W5 Behavioral studies on thermal, mechanical, and spontaneous pain (demonstration of Ugo Basile equipment)
    Federico Montechiaro (Ugo Basile Srl, Gemonio, Italy)
    16:00-16:15 S22 Sciatic nerve inflammation in diabetic neuropathy
    Sara Hakim (Boston, MA, USA)
    16:15-16:30 Sensory neuron-associated macrophages proliferate in the sensory ganglia after peripheral nerve injury in a CX3CR1 signaling dependent manner
    Conceição Elidianne Aníbal Silva (Ribeirão Preto, São Paulo, Brazil)
    16:30-16:45 S24 The constitutive activity of spinal 5-HT6 receptors contributes to diabetic neuropathic pain in rats
    Nazarine Mokhtar (Clermont-Ferrand, France)
    16:45-17:15 Coffee break
    17:15-17:30 S25 Inflammation and endocrine disruptors: effects on the oxidative status of human astrocytes
    Serena Nencini (Siena, Italy)
    17:30-17:45 S26 ZFHX2, a novel gene involved in congenital hypoalgesia
    Lucrezia Paradisi (Siena, Italy)
    17:45-18:45 L11 Macrophages and Schwann cells interacting with nociceptors in disease models
    Romina Nassini (Florence, Italy)
    20:00-21:30 Dinner
    21:30 W6 Star gazing


  • Wednesday, 14 June

    9:00-10:00 L12 Peripheral glial cells regulate neurogenic inflammatory pain: relevance for primary headaches
    Pierangelo Geppetti (Florence, Italy)
    10:00-10:15 S27 The role of meningeal immune cells in the efficacy of CGRP-based migraine therapies
    Talia Adi (Pittsburgh, PA, USA)
    10:15-10:30 S28 High sensitivity C - reactive protein as a marker for temporomandibular pain: an 11-year follow-up study on Finnish adults
    Aisha Banafa (Kuopio, Finland)
    10:30-10:45 S29 Functional coupling among Piezo1, TRPV1, and TRPA1 in rat odontoblasts
    Ryuya Kurashima (Tokyo, Japan)
    10:45-11:15 Coffee break
    11:15-11:30 S30 The effect of vincristine on pro-nociceptive cytokine release from macrophages
    Ammar Alshammari (St Lucia, QLD, Australia)
    11:30-11:45 S31 IL-1 mediates chronic stress-induced hyperalgesia accompanied by microglia and astroglia morphological changes in pain-related brain regions in mice
    Barbara Fülöp (Pécs, Hungary)
    11:45-12:45 L13 Molecular architecture of somatic sensory neurons
    Patrik Ernfors (Stockholm, Sweden)
    12:45-15:00 Lunch break
    Excursion Montalcino Castello Banfi and Bagno Vignoni (Albergo Le Terme)
    20:00 Apericena


  • Thursday, 15 June

    9:00-10:00 L14 Nociceptor regulation of barrier tissue immunity and host defense
    Isaac Chiu (Boston, MA, USA)
    10:00-10:30 W7 Duetto Transcriptomics versus proteomics of sensory neurons: what predicts chronic pain?
    John N. Wood (London, United Kingdom) and Patrik Ernfors (Stockholm, Sweden)
    10:30-10:45 S32 Investigating neutrophil-neuron interactions that modulate somatosensory processing and chronic widespread pain
    Romy Evans (London, United Kingdom)
    10:45-11:15 Coffee break
    11:15-11:30 S33 The comprehensive investigation of pain and inflammation in difficult-to-treat rheumatoid arthritis from a multidisciplinary approach
    Lilla Gunkl-Tóth (Pécs, Hungary)
    11:30-11:45 S34 Nocifensive behavior responses to laser-delivered heat stimuli reveal thermal hypoalgesia in both glucose-driven and methylglyoxal-driven larval zebrafish models of diabetes
    Jonathan Husk (Heidelberg, Germany)
    11:45-12:45 L15 Plasticity and redundancy in  pain pathways
    John N. Wood (London, United Kingdom)
    12:45-15:00 Lunch break
    15:00-16:00 L16 Microbial activation of pain and itch in infection
    Isaac Chiu (Boston, MA, USA)
    16:00-16:15 S35 Influence of anesthetics on glymphatic cerebrospinal fluid flow: a dynamic whole-body dynamic single-photon emission tomography imaging study in mechanically ventilated rats
    Niklas Daniel Åke Persson (Helsinki, Finland)
    16:15-16:30 S36 Study of the relationship between diet and inflammatory mediators in chronic pain diseases
    Ilenia Casini (Siena, Italy)
    16:30-16:45 S37 Top-down attentional modulation does not affect the development of secondary hyperalgesia: an experimental investigation
    Delia Della Porta (Brussels, Belgium)
    16:45-17:15 Coffee break
    17:15-17:30 S38 Lipedema patients show a distinctly altered quantitative sensory testing (QST) profile with promising diagnostic potential
    Rebecca Dinnendahl (Cologne, Germany)
    17:30-17:45 S39 Disentangling the contribution of gender roles and sex hormones on sex differences in chronic pain across multiple large population cohorts
    Gianluca Guglietti (Montreal, Canada)
    17:45-18:45 L17 Nociceptive Schwann cells in pain
    Patrik Ernfors (Stockholm, Sweden)
    20:00-21:30 Dinner


  • Friday, 16 June

    9:00-10:00 L18 Hormonal modulation of pain
    Anna Maria Aloisi (Siena, Italy)
    10:00-10:30 W8 Debate 1
    Can we really kill chronic pain and go unpunished?
    10:30-11:00 Coffee break
    11:00-11:30 W9 Debate 2
    Are immune cells a valid target for chronic pain?
    11:30-11:45 W10 Pain Quiz
    11:45-12:45 Conclusion and Closing
    12:45-15:00 Lunch break
    15:00-19:00 Excursion to Siena (guided tour, strolling and shopping, leisure time)
    20:00 Farewell dinner and party


  • Saturday, 17 June